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What Is a Neuropeptide Facial Cream?

By T. Forsythe
Updated May 21, 2024
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A neuropeptide facial cream is a cosmetic product designed to combat aging by strengthening the skin’s natural proteins and collagen fibers while numbing the nerve endings that allow for wrinkle formation in the first place. There can be a lot of variety between manufacturers, and not all products bearing the “neuropeptide” name operate in quite the same way. The main idea behind all of them is about the same, though, which is to harness the chemical powers of amino acids to reduce wrinkles and make skin appear smoother, firmer, and younger. Most also target the nerves of the face and seek to temporarily immobilize them or paralyze them, which also reduces the likelihood of wrinkling. These lotions are usually available over the counter in pharmacies and health and beauty stores, since the chemicals they contain aren’t typically strong enough to require a prescription. They tend to be less expensive than other more intensive treatments designed to treat facial aging, but in most places they are still quite costly, especially over time. Constant, daily use is usually recommended for good results.

Main Goal

People buy these sorts of products in order to improve the look and feel of the skin on their faces, particularly the delicate areas around the eyes. They work a lot like any other thick facial cream but with the added benefit of neuropeptides. Neuropeptides, which are chains of complex amino acids derived from both nature and synthetic creations, are designed to interact with collagen to renew glow, strength, and elasticity of skin tissues.

The peptide chains of amino acids that are found naturally in the human body are also found in neuropeptide facial lotions and creams. When rubbed onto the face, these peptides interact with strands of collagen proteins that are about to break down to keep them soluble and intact. The facial cream also contains anti-inflammatory properties that reduce the destruction of collagen.

Chemical Attributes

The “neuro” part of the “neuropeptide” name refers to a type of chemical transmitter that sends messages to skin cells. Many facial movements, such as squinting, are repeated many times each day; over years, this causes wrinkles and furrows to form. When the neuropeptide facial cream is applied, a signal is sent to block the nerve that contracts that area of the face so that the muscle tightens and skin becomes more smooth.

Understanding Collagen Generally

Most of the action is centered on collagen production and strengthing. Collagen is comprised of a type of grid that holds skin together. It breaks down naturally with age, though deterioration and damage are often accelerated by exposure to the sun or toxins such as smoking or alcohol. When more collagen is developed or inflammation is reduced with an anti-aging cream, skin tightens and becomes firmer and smoother.

Effectiveness and Differences in Product Quality

Reviews are somewhat mixed as to the efficacy and viability of using neuropeptide facial creams. Many users claim instant results when it comes to skin smoothing; this is usually owing to the cream’s nerve dulling properties. Wrinkles are said to diminish and ultimately disappear over time, and fewer signs of aging are supposed to appear in the meantime. Not everyone sees these results, though, and they’re often more pronounced in some people than others.

It’s important to keep in mind that there is no universal formula for what a neuropeptide facial lotion or cream should be. There can be a lot of variety when it comes to what manufacturers include, and at what concentrations. Results achieved or not achieved with one product aren’t likely to be applicable to every cream in the category.

Common Alternatives

People who are looking to improve the face’s appearance and texture typically have a number of options. Immobility is the same concept used in treatments like Botox®, though these tend to be painful and can have severe side effects. Most injection-based solutions must be repeated every few months to keep consistent results. Surgery is another option, though this is also invasive, expensive, and can be quite risky. Neuropeptide facial cream uses natural ingredients that may produce anti-aging effects without the risks associated with other treatments. The results aren’t usually as profound, but are usually still noticeable.

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Discussion Comments

By myharley — On Dec 17, 2011

I recently went to a home skin care session, and couldn't believe how much everything cost. If I would have bought just the basic set they were recommending for regular skin care, I would have been out more than $200.

Honestly, I don't know who can afford to keep using products like this. Even if they work as good as they say they do, I am not going to worry about a few wrinkles here and there.

It does make sense to me to replenish aging skin with protein and collagen, so I can see where collagen creams have a place.

I guess it just depends on where your priorities are. I am content with making sure my skin is clean and moisturized and spend the money on something else.

By golf07 — On Dec 16, 2011

I have not found any of the anti aging serums to be very inexpensive. You can expect to pay anywhere from $40 on up to $100 for a bottle.

The brand I currently use costs about $60 and lasts me right around 6 months. I figure $10 a month is not too expensive and a lot less than having any kind of surgery done.

When I put this cream around my eyes, I can feel it tighten, so know it is helping at least temporarily. I don't expect to totally get rid of the wrinkles as I age, I just want to slow down the process a little bit.

People always tell me I look younger than I am, so that is good enough for me to continue using these creams.

By bear78 — On Dec 15, 2011

@ddljohn-- I'm not sure which brand you're using but none of the neuropeptide creams I have seen are very affordable. They're actually pretty expensive.

I do have deep wrinkles, sagging and bags under my eyes and I have not really benefited from neuropeptide cream. I can't speak for all the types and brands out there, but the only thing it really did for me was to moisturize my skin well. And that might be one of the reasons it's good for fine lines and some wrinkles. But I definitely don't think that it has reduced my wrinkles enough to be worth the price I paid for it.

I would like to hear what other people have to say about this cream though. Maybe I'm using the wrong brand, I don't know.

By ddljohn — On Dec 15, 2011

@simrin-- It might work similarly to botox that way, but it certainly does not cause a loss of facial expression. I've been using one for the past six months and I certainly haven't seen anything like that.

I completely agree with the article that neuropeptide cream is much better than botox and surgery. Botox is not that expensive, but it's temporary like the article said and surgery is too expensive and painful. At lease neuropeptide facial cream is something that's absorbed into the skin and works with the skin cells. Plus it's very affordable.

I love taking care of my skin and I want to look younger than my age but I prefer to do this as naturally as I can. Since I've started using this cream, most of my fine lines have completely disappeared. I don't have deep wrinkles so I can't say anything about that; but as someone in her late thirties, I love this anti-wrinkle cream. It's working really well for me.

By SteamLouis — On Dec 14, 2011

Isn't it immobility that causes people to lose the ability to make face expressions?

The article mentions that neuropeptides make the skin immobile because that's how it decreases the appearance of facial wrinkles and makes the skin tighter. It also mentions that this is the same technique used in botox.

As far as I know, the main problem that people have with botox is that it takes away the ability to move one's face and you are no longer able to make expressions. In fact, many actresses have stopped using botox for this same very reason.

Will neuropeptide cream also have the same effect on the face?

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